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In a double-blind, placebo-controlled, dose-titration study, 1 to 3 g/day of oral propionyl-L-carnitine for 24 weeks was well tolerated and improved maximal walking distance in patients with intermittent claudication (64)
Lyophilized peptides require proper reconstitution with bacteriostatic water
The nausea at higher doses without adequate adaptation can be severe enough to force protocol abandonment entirely
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Low (1 vial) would be sufficient for limited use, a short-term need, or sampling purposes only
Medications known to decrease vitamin B12 levels
Others are navigating legal challenges to the FDA mandate
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